What question did this study set out to answer?

The aim is to compare the efficacy of different treatments for moderate to severe psoriasis.

Comparison of various psoriasis treatment methods

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Randomized trial compares effectiveness of topical, systemic, and biological treatments for psoriasis, suggesting targeted therapy improves outcomes.

The aim is to compare the efficacy of different treatments for moderate to severe psoriasis.
Included 155 patients aged 18 to 78 with moderate to severe psoriasis.
Patients were assigned to three groups: topical mometasone, systemic methotrexate, or IL-17 inhibitor netakimab.
Effectiveness was measured using PASI and BSA indices.
In the topical treatment group, median PASI decreased by 2.78% and median BSA by 3.13%.
In the methotrexate group, median PASI decreased by 21.05% and median BSA by 33.33%.
In the IL-17 inhibitor group, median PASI decreased by 73.68% and median BSA by 78.95%, with significant decline in psoriatic arthritis complaints.

Аrsenyeva et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial compares effectiveness of topical, systemic, and biological treatments for psoriasis, suggesting targeted therapy improves outcomes.

The aim is to compare the efficacy of different treatments for moderate to severe psoriasis.
Included 155 patients aged 18 to 78 with moderate to severe psoriasis.
Patients were assigned to three groups: topical mometasone, systemic methotrexate, or IL-17 inhibitor netakimab.
Effectiveness was measured using PASI and BSA indices.
In the topical treatment group, median PASI decreased by 2.78% and median BSA by 3.13%.
In the methotrexate group, median PASI decreased by 21.05% and median BSA by 33.33%.
In the IL-17 inhibitor group, median PASI decreased by 73.68% and median BSA by 78.95%, with significant decline in psoriatic arthritis complaints.

Аrsenyeva et al. (2026) studied this question.

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