BMP2 Pan-Cancer Analysis in Multiple Tumor Types of TCGA Datasets *

Abstract This BMP2 is an indispensable gene in bone development and repair across vertebrates. The relation between BMP2 expression level and tumor genesis/progression has been reported previously. In this study, we use The Cancer Genome Atlas datasets (TCGA) to explore possible effect of BMP2 in different tumors. Among many tumor types in TCGA datasets, BMP2 has a higher expression level in tumor tissues in contrast with corresponding normal tissues in CHOL, GBM, HNSC, KIRC, LIHC patients. On the other hand, BMP2 has a lower expression in tumor tissues when compared to corresponding normal tissues in patients of BLCA, BRCA, COAD, KICH, LUAD, LUSC, PRAD, READ, THCA, UCEC tumors. Among ECSA, LIHC, LUHC, PAAD, THCA patients, a higher BMP2 expression level was related with a less overall survival time. In UVM tumor, higher BMP2 expression level correlated with less disease-free survival times. BMP2 have different expression in different stages of KIRC, THCA patients. Further BMP2 genetic alteration analysis revealed that gene mutation and amplification are the two most common genetic alteration in most TCGA datasets tumors. BMP2 genetic alteration has an impact on ACC, LGG, CESC, LIHC, PRAD, THYM, UCEC prognosis. The expression level of BMP2 has a positive correlation with tumor-associated fibroblast infiltration in BRCA, HNSC, LIHC, LUSC, MESO, OV, PCPG, PRAD, SARC, SKCM, TGCT, THCA, THYM, UCEC, UVM tumors. The protein interaction plot showed that BMP2 virtually interacted with ACVR2A, BMP4, BMPR2, BMPR1A, BMPR1B, CALR and HSPA5 proteins. Further Kyoto Encyclopedia of Genes and Genomes analysis result shows that BMP2 has the closest relation with TGF-β signaling pathway. In conclusion, this Pan-cancer study has unraveled the expression of BMP2 among various TCGA tumors, the related biological mechanism as well as the tumor-related prognosis.