Guanidine hydrochloride assisted one-pot synthesis of 2-amino-4,6- disubstituted-3-cyanopyridine derivatives: a sustainable and greener strategy with catalyst recyclability

Abstract Here, we highlight an efficient and novel approach for the one-pot multicomponent preparations of 2-amino-4,6-disubstituted-3-cyanopyridine derivatives through the cyclo-condensation of substituted aromatic aldehydes, ammonium acetate, malononitrile, and aryl ketones under neat conditions. This study presents a novel approach for the preparations of 2-amino-4,6-disubstituted-3-cyanopyridine derivatives with numerous advantages, such as rapid reaction, environmentally friendly conditions, a broad range of compatible substrates, catalyst recyclability, and a simple workup process. The reported method harnesses the catalytic potential of guanidine hydrochloride, serving as a highly effective organo-catalyst, which exhibits exceptional mildness and catalytic activity, facilitating the reaction with high yield.