Advances in Multicomponent Synthesis of 2-Amino-3-Cyanopyridine Derivatives

Over the past decade, there has been remarkable progress in the production of physiologically significant and architecturally varied 2-amino-3-cyanopyridine derivatives, achieved through the adoption of green chemistry. The most recent developments in the environmentally friendly multicomponent green synthesis of 2-amino-3-cyanopyridine and its derivatives are highlighted in the current review. Significant advancements encompass the implementation of energy-efficient methods, including microwave and ultrasound-assisted synthesis, along with the implementation of benign catalysts, including carbocatalysts, transition metal catalysts, phase transfer catalysts, organocatalysts, photocatalysts, acidic nano catalysts, and biodegradable composites. Additionally, the review emphasizes the importance of solvent selection, especially the benefits of solvent-free circumstances and the application of water as a recuperative and non-poisonous medium. This study is a useful resource for academics dedicated to developing green chemical practices by synthesizing existing information and defining future research paths.