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Abstract Purpose: The prognostic value of the Naples prognostic score in lung cancer remains controversial. Therefore, we performed a meta-analysis of relevant published studies to determine the prognostic value of the Naples prognostic score in patients with lung cancer. Methods: We conducted a systematic search of relevant studies in PubMed, Ovid, the Cochrane Library, and Web of Science databases. Data and characteristics of each study were extracted and hazard ratios (HRs) at 95% confidence intervals (CIs) were calculated to estimate effects. A meta-regression analysis was used to assess the prognostic value of the Naples Prognostic Score in patients with lung cancer. Results: A total of 1691 patients from six studies were included in this meta-analysis, with a combined HR of 3.357 (95% CI: 1.964-5.738, p=0.000); the results suggest that a high Naples Prognostic Score predicts a shorter overall survival (OS) for patients. Conclusion: This meta-analysis suggests that a high Naples Prognostic Score may be a predictor of poor prognosis in lung cancer patients. Further large cohort studies are needed to confirm these findings.
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Han et al. (2024) studied this question.
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