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Meta-analysis reveals Naples Prognostic Score predicts poor overall survival in lung cancer, suggesting further studies are necessary.
The prognostic value of the Naples prognostic score in lung cancer remains controversial. Therefore, we performed a meta-analysis of relevant published studies to determine the prognostic value of the Naples prognostic score in patients with lung cancer. We conducted a systematic search of relevant studies in PubMed, Ovid, the Cochrane Library, and Web of Science databases. Data and characteristics of each study were extracted and hazard ratios (HRs) at 95% confidence intervals (95% CI) were calculated to estimate effects. A meta-regression analysis was used to assess the prognostic value of the Naples Prognostic Score in patients with lung cancer. A total of 1691 patients from six studies were included in this meta-analysis, with a combined HR of 3.357 (95% CI: 1.964–5.738, P < 0.001); the results suggest that a high Naples Prognostic Score predicts a shorter overall survival (OS) for patients. This meta-analysis suggests that a high Naples Prognostic Score may be a predictor of poor prognosis in lung cancer patients. Further large cohort studies are needed to confirm these findings.
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Liu et al. (2026) studied this question.
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