Expression of Extracellular Matrix Metalloproteinase Inducer (Emmprin) as a Biomarker in Oral Squamous Cell Carcinoma (Oscc)

EMMPRIN is a widely distributed cell surface glycoprotein that belongs to immunoglobulin (Ig) super family. It isinducing the production of extracellular matrix metalloproteinase (MMP) enzymes and play important role in angiogenesis via stimulation of vascular endothelial growth factor (VEGF). The aim of the present work is to evaluate andasses the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in oral squamous cell carcinomasand to compare the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in different types oforal squamous cell carcinomas. Thirty diagnosed cases of Oral squamous cell carcinoma (OSCC) were selected andimmunohistochemistry was performed for EMMPRIN. All cases showed positive EMMPRIN expression with different intensity. This study concluded that the elevated expression of EMMPRIN levels correlate with tumor proliferation, angiogenesis, metastasis and invasion.