A Completely Disposable Screen-Printed Electrode for The Electrochemical Detection of Sunitinib Malate

Sunitinib malate (STB) is a targeted therapy for colorectal cancer, necessitating precise dosage due to potential severe side effects from overdose.Therapeutic drug monitoring (TDM) is crucial for maintaining optimal drug levels in body fluids.Traditional anticancer drug dose evaluation methods such as High-Pressure Liquid Chromatography (HPLC), Liquid chromatography with Mass Spectrophotometry (LCMS), and immunoassays are cumbersome.This study explores the utilization of electrochemical sensors on screen-printed electrodes (SPEs) for STB monitoring.Differential pulse voltammetry (DPV), cyclic voltammetry (CV), and amperometric studies were conducted in a conventional three-electrode SPE system.An anodic peak current, indicative of STB electro-oxidation, was observed around +0.45 V. Sensitivity and Limit of Detection (LOD) were determined as 0.386 μAμM -1 cm -2 and 0.009 μM, respectively.The response exhibited linearity (R 2 = 0.990) with STB concentration ranging from 80 nM to 88 μM so the sensor showed a dynamic range of 80 nM to 88 μM, with good reproducibility.DPV studies on real samples yielded acceptable recovery values.Electrochemical sensors on SPEs present a promising approach for STB monitoring, offering sensitivity, low LOD, and a wide linear range.The expected plasma concentration of sunitinib is much higher than the sensor's detection range; the sensor can be used for real sample analysis.This method can potentially simplify and improve therapeutic drug monitoring in colorectal cancer treatment.