Efficacy of Intravenous Magnesium Sulphate in Attenuating Hemodynamic Response in Hypertensive Patients to Laryngoscopy and Endotracheal Intubation

Objective: To determine the efficacy of intravenous Magnesium Sulphate in attenuating the hemodynamic response, Systolic Blood Pressure, in hypertensive patients undergoing laryngoscopy and endotracheal intubation compared with a Control Group. Study Design: Quasi-experimental study. Place and Duration of Study: Anesthesia Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Apr to Oct 2018. Methodology: A total of 110 diagnosed patients of hypertension, taking anti-hypertensive medication, between 30–65 years of age, belonging to either gender, and undergoing elective surgery were enrolled. Patients were given intravenous Magnesium Sulphate (30 mg/kg) in 20 ml normal saline over a period of 03 minutes before induction of general anesthesia while control Group was given 20 ml of normal saline (placebo). Systolic Blood Pressure for both Groups was recorded on a performa by an observer two minutes after intubation. Results: The mean age of patients in treatment Group was 43.95±8.39 years and in control Group, 43.84±8.36 years. Out of 110 patients, 41(37.27%) were males and 69(62.73%) were females. The efficacy of MgSO4 was 16(29.09%) and in control Group, it was 04(7.27%) with p-value of 0.003(<0.05). Conclusion: Intravenous Magnesium Sulphate is efficacious in attenuating hemodynamic response to laryngoscopy and intubation in hypertensive patients.