Key result
Lidocaine blunted the hemodynamic stress response to intubation in 67.2% of hypertensive patients compared to 47.4% with Magnesium Sulphate (p=0.003).
Why the study?
To compare the blunting of the hemodynamic stress response to intubation using Magnesium Sulphate versus Lidocaine in hypertensive patients.
Does Lidocaine compared to Magnesium Sulphate improve blunting of hemodynamic stress response to intubation in hypertensive patients?
RCT (n=232)
Lottery method
No
Does Lidocaine compared to Magnesium Sulphate improve blunting of hemodynamic stress response to intubation in hypertensive patients?
Absolute Event Rate: 67.2% vs 47.4%
p-value: p=0.003
Lidocaine 1.5 mg/kg is more effective than Magnesium Sulphate 30 mg/kg in blunting the hemodynamic stress response to intubation in hypertensive patients.
Establishes intravenous lidocaine as the preferred agent for attenuating intubation-related.
Objective: To compare blunting of hemodynamic stress response to intubation using Magnesium Sulphate versus Lidocaine in hypertensive patients. Study Design: Prospective comparative study. Place and Duration of Study: Anaesthesia Department Combined Military Hospital, Lahore Pakistan, from Jan to Jun 2019. Methodology: A total of 232 hypertensive patients of the ASA status II, undergoing elective surgical procedures requiring intubation, were randomly divided into two groups, Group-L (Lidocaine) and Group-M (Magnesium Sulphate). Lidocaine 1.5mg/kg was given to Group-L 90 seconds before laryngoscopy, whereas Magnesium Sulphate 30mg/kg was given over ten minutes to Group-M before laryngoscopy. Baseline means arterial pressure was recorded. Mean arterial pressure was subsequently recorded each minute after intubation for five minutes. Results: Both groups were similar with regard to demographic data. After intubation, both groups had an increase in mean arterial pressures. Blunting of stress response was observed in 78 patients (67.2%) in Group-L and 55 patients (47.4%) in Group-M. Two groups showed a significant statistical difference (p=0.003).Conclusion: Both drugs are effective in blunting hemodynamic stress response to intubation in hypertensive patients, but Lidocaine is more effective than Magnesium Sulphate.
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Feroze et al. (2022) conducted an RCT in Controlled hypertension requiring intubation for elective surgery (n=232). Lidocaine vs. Magnesium Sulphate 30 mg/kg IV was evaluated on Blunting of stress response (prevention of >20% increase in baseline mean arterial pressure) (p=0.003). Lidocaine blunted the hemodynamic stress response to intubation in 67.2% of hypertensive patients compared to 47.4% with Magnesium Sulphate (p=0.003).
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