Key result
IV magnesium sulphate reduces post-intubation heart rate by ~9% and lowers MAP vs lignocaine.
Why the study?
Laryngoscopy and endotracheal intubation produce hemodynamic pressor responses, and strategies to attenuate these responses including intravenous magnesium sulphate and lignocaine were tested.
Does intravenous magnesium sulphate reduce hemodynamic stress during laryngoscopy and intubation compared to intravenous lignocaine in patients undergoing elective surgery?
RCT (n=60)
Double-blind
Randomized
No
Does intravenous magnesium sulphate reduce hemodynamic stress during laryngoscopy and intubation compared to intravenous lignocaine in patients undergoing elective surgery?
Absolute Event Rate: 78.57% vs 86.3%
p-value: p=0.0001
Intravenous magnesium sulphate is more effective than lignocaine in attenuating hemodynamic stress responses during laryngoscopy and intubation.
Magnesium sulphate may blunt intubation responses more than lignocaine; leaves open optimal dosing and practice change pending larger trials.
Background: Following induction of general anesthesia, laryngoscopy and endotracheal intubation produce pressor response that are somatic visceral reflexes brought on by stimulation of epipharynx and laryngopharynx. To avoid hemodynamic responses to intubation, several strategies have been tested. Agents like opioids, local anesthetics have been used to attenuate such response. Our study was employed with intravenous magnesium sulphate and lignocaine. Methods: A total of 60 patients of both sexes in the age group between 15-50years, belonging to ASA grade I and II undergoing elective surgery under general anaesthesia. Out of the 60 patients 30 were randomly included in the L group (lignocaine group) and the other 30 were included in the M group (magnesium sulphate group). Results: There was fall in heart rate (p < 0.05) noted following induction, laryngoscopy, and intubation, in Magnesium group and Lignocaine group, but the fall in heart rate was more significant in the Magnesium group when compared with the Lignocaine group Like heart rate there was a significant fall in mean arterial pressure in both the groups, but there was statistically significant fall (p < 0.05) in the Magnesium group when compared with the Lignocaine group.
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P et al. (2023) conducted an RCT in Haemodynamic stress during laryngoscopy and intubation (n=60). Magnesium sulphate vs. Lignocaine 1.5 mg/kg IV was evaluated on Heart rate at 1 minute post-intubation (p=0.0001). Intravenous magnesium sulphate (30 mg/kg) significantly reduced heart rate (78.57 vs 86.3 bpm) and mean arterial pressure (79.83 vs 88.70 mmHg) at 1 minute post-intubation compared to lignocaine (p=0.0001).
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