A Novel and Easy Synthesis of 1H-Tetrazoles employing p-Tolenesulfonyl azide

A novel and easy method for the synthesis of tetrazole is from substituted amides using p-toluene sulfonyl azide for activating amide-oxygen for elimination and azide source. In this protocol, various substituted amides were transformed to tetrazoles of high yields. This protocol is a convenient method for the synthesis of 5-substituted 1H-tetrazoles without using explosive or toxic reagents. Most of the synthesized compounds are anticancerous to the cancer cell lines HeLa, MCF-7 and U87-MG. Among the synthesized compounds, compound 4b was found to be most promising anticancerous to all three cancer cell lines.