Initial Trans-Arterial Chemo-Embolisation (TACE) Is Associated with Similar Survival Outcomes as Compared to Upfront Percutaneous Ablation Allowing for Follow-Up Treatment in Those with Single Hepatocellular Carcinoma (HCC) ≤ 3 cm: Results of a Real-World Propensity-Matched Multi-Centre Australian Cohort Study

Jonathan Abdelmalak; Simone I. Strasser; Natalie Ngu; Claude Dennis; Marie Sinclair; Avik Majumdar; Kate Collins; Katherine Bateman; Anouk Dev; Joshua Haron Abasszade; Zina Valaydon; Daniel Saitta; Kathryn Gazelakis; Susan Byers; Jacinta A. Holmes; Alex J. Thompson; Jessica Howell; Dhivya Pandiaraja; Steven Bollipo; Suresh Sharma; Merlyn Joseph; Rohit Sawhney; Amanda Nicoll; Nicholas Batt; Myo J. Tang; Stephen M. Riordan; Nicholas Hannah; James Haridy; Siddharth Sood; Eileen Lam; Elysia Greenhill; John Lubel; William Kemp; Ammar Majeed; John Zalcberg; Stuart K. Roberts

doi:10.3390/cancers16173010

August 29, 2024CancersOpen Access

Initial Trans-Arterial Chemo-Embolisation (TACE) Is Associated with Similar Survival Outcomes as Compared to Upfront Percutaneous Ablation Allowing for Follow-Up Treatment in Those with Single Hepatocellular Carcinoma (HCC) ≤ 3 cm: Results of a Real-World Propensity-Matched Multi-Centre Australian Cohort Study

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Key Points

Initial trans-arterial chemo-embolisation demonstrates similar overall survival compared to upfront percutaneous ablation in patients with single hepatocellular carcinoma ≤ 3 cm.
Overall survival showed no significant difference among 230 propensity-matched patients undergoing initial chemo-embolisation or ablation across Australian hospital cohorts.
Multi-centre cohort study of 230 propensity-matched patients highlights initial chemo-embolisation as a viable real-world alternative to upfront percutaneous ablation.

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Implication

Cohort study finds similar overall survival between chemo-embolisation and upfront ablation in single small hepatocellular carcinoma, indicating chemo-embolisation is an effective alternative.

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Abdelmalak et al. (2024) studied this question.

synapsesocial.com/papers/68e5a5f5b6db643587540445 https://doi.org/10.3390/cancers16173010

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