Lipomas are non-cancerous growths made up of mature fat cells and are considered the most common type of tumor, with an estimated occurrence rate of 10%. They can develop anywhere in the body, typically weighing a few grams and usually measuring less than 2 cm in size. Liposarcomas, on the other hand, represent 10% to 35% of all soft tissue sarcomas, comprising 24% of those found in the limbs and 45% in the abdominal cavity. These tumors can emerge in any area where fat is present and exhibit a variety of histological features, as well as diverse imaging characteristics and behaviors. We have studied a case of a 56-year-old male patient who presented with a complaint of swelling in left thigh since last 4 years, which varied in size with time. The patient was investigated and underwent surgical excision. diagnosis of liposarcoma was confirmed with histology. Lipomas have the potential to transform into one of three types of liposarcomas. Therefore, it is crucial to reevaluate the conventional view of all lipomas as benign growths and consider diverse approaches, as they can occasionally progress to a sarcomatous state. Aggressive forms often require a combination of surgery, chemotherapy, and radiation therapy for treatment. It is crucial to distinguish between different subtypes of liposarcomas due to their significant implications for treatment and prognosis. Liposarcomas tend to affect individuals aged 40 to 60 years, with an equal likelihood in both men and women.
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Nathani et al. (2024) studied this question.
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