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August 27, 2024Artificial OrgansOpen Access

Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study

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Authors

AFAlborz FeiziJDJenna DiRitoOROwen Richfield

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Overview

Proof-of-concept study shows contrast-enhanced computed tomography evaluates vascular function in transplant-declined human kidneys, highlighting noninvasive whole-organ assessment.

Key Points

  • Imaging revealed variable vascular responses in two human kidneys after a 1-h period of ex vivo normothermic perfusion, with altered vessel size in one organ.
  • Ex vivo cold infusion scanning with contrast-enhanced computed tomography was used to measure perfusion heterogeneity and vascular network structure in six kidneys.
  • Supports noninvasive whole-organ evaluation during ex vivo perfusion, potentially eliminating biopsy-induced damage while characterizing organ-level vascular function.

Cite This Study

Feizi et al. (2024) studied this question.

synapsesocial.com/papers/68e5ab93b6db6435875458cfhttps://doi.org/10.1111/aor.14840
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