Ultrasound assisted solvent-free approach for the synthesis of 4-thiazolidinone derivatives

An economical and environment-friendly protocol involving the use of ultrasonic vibrations was developed for the synthesis of a series of diaryl-4-thiazolidinones. The highlights of the developed approach are significant enhancement in the product yield, short reaction time, solvent-free, free of any toxic metal as a catalyst, cheaper synthetic methodological approach as well as non-formation of side-products. The developed approach is useful in terms of immense biological relevance of thiazolidines as well as the greener approach for cyclo-condensation of functionalized imines with thioglycolic acid.