Dose and local efficacy analysis of iodine-125 seed implantation therapy for lung tumors

Abstract Objective To explore the dose and local efficacy of iodine-125 seed implantation therapy for lung tumors. Methods The clinical data of 85 patients with lung tumors who underwent iodine-125 seed implantation therapy were retrospectively analyzed. The impact of prescription dose D90 (minimum peripheral dose received by the 90% target volume) on the local treatment effect six months after seed implantation was analyzed, and the critical value for predicting efficacy was determined. Factors affecting the local complete response (CR) rate six months after surgery were also analyzed. Results The local control rate six months after treatment was 89.41% (76/85), and the overall response rate (CR + PR) was 70.59% (60/85), with a CR rate of 31.76% (27/85). Patients with a postoperative D90 > 140 Gy had a significantly greater local CR rate. Multivariate analysis revealed that postoperative D90 and tumor size were independent prognostic factors for achieving CR six months after lung tumor seed implantation. Conclusion Iodine-125 seed implantation therapy is effective for lung tumors. Tumor size (P = 0.0003) and postoperative D90 (P = 0.0005) were found to be independent prognostic factors for achieving postoperative CR after lung tumor seed implantation.