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August 23, 2024The Lancet Regional Health - AmericasOpen Access

AI-guided identification of risk variants for adrenocortical tumours in TP53 p.R337H carrier children: a genetic association study

Bonald C. Figueiredo Florent Dupont Geoffrey Portelli Tatiana E J Costa Gislaine Custódio Mariana M. Paraizo Heloísa Komechen Hadrien Gascuel Maxime Bottau Elodie Callea Ana Paula Percicote Leila G Telles M. Jendoubi Enzo Lalli

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Abstract

Adrenocortical tumours (ACT) in children are part of the Li-Fraumeni cancer spectrum and are frequently associated with a germline

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Figueiredo et al. (2024) studied this question.

synapsesocial.com/papers/68e5b296b6db64358754c280 https://doi.org/10.1016/j.lana.2024.100863

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1SNP Array Profiling of Childhood Adrenocortical Tumors Reveals Distinct Pathways of Tumorigenesis and Highlights Candidate Driver Genesother · 2012 · 54 citations
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4Clinical and surveillance outcomes of the TP53 c.1000G > C (p.Gly334Arg) variantRetrospective Study · 2026
5Tumor Spectrum and Temporal Cancer Trends in adult carriers of Li-Fraumeni syndrome: Implications for Personalized Screening Strategies in<i>TP53</i>R337H carriers2024