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August 22, 2024eLifeOpen Access

A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

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Authors

SNSerena NotartomasoNANico AntenucciMMMariacristina Mazzitelli

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Cite This Study

Notartomaso et al. (2024) studied this question.

synapsesocial.com/papers/68e5b4dfb6db64358754d741https://doi.org/10.7554/elife.94931
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1mGlu2 Metabotropic Glutamate Receptors Restrain Inflammatory Pain and Mediate the Analgesic Activity of Dual mGlu2/mGlu3 Receptor Agonists2011 · 53 citations
  2. 2Enhanced Anti-Nociception by Novel Dual Antagonists for 5-HT2AR and mGluR5 in Preclinical Models of Pain2025 · 1 citations
  3. 3An Agonist Concentration Biased NMDA Receptor Modulator Produces Analgesic Activity in Experimental Animals2024
  4. 4Red nucleus mGluR1 and mGluR5 facilitate the development of neuropathic pain through stimulating the expressions of TNF-α and IL-1β2024 · 4 citations
  5. 5Photogenetics Inhibits the Activity of Glutamate Neurons Projected from the Motor Cortex to the Ventroposterolateral Nucleus of the Thalamus to Alleviates Central Post-Stroke Pain in Rats2024