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December 20, 2025Neuropsychopharmacology

In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain

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Authors

MDMargaret T. DavisEWEmily R. WeissNDNicole DellaGioia

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Overview

Findings reveal chronic pain reduces mGlu5 availability in brain regions linked to depression and anxiety.

Key Points

  • Investigate the association between metabotropic glutamate receptor 5 availability and chronic pain in various psychiatric populations.
  • Transdiagnostic sample of 112 individuals underwent clinical assessments and PET scans.
  • Participants included those with chronic pain, major depressive disorder, bipolar disorder, and healthy controls.
  • mGlu5 availability was measured in brain regions associated with pain perception.
  • mGlu5 availability was found to be 13.5-15.7% lower in individuals with chronic pain compared to those without pain.
  • Exploratory analyses indicated even lower availability in individuals with chronic pain vs. acute pain only.
  • Negative associations were observed between mGlu5 availability and levels of depression and anxiety.

Cite This Study

Davis et al. (2025) studied this question.

synapsesocial.com/papers/6945ea41742299010fff02e4https://doi.org/10.1038/s41386-025-02296-9
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