What does this research mean for the field?

Patients with chronic low back pain exhibit a lower excitatory/inhibitory neurotransmitter tone (decreased Glx and increased GABA) in the periaqueductal grey and disrupted associations with pain sensitivity, suggesting altered descending pain inhibition. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 5, 2023Open Access

The periaqueductal grey in chronic low back pain: dysregulated metabolites and function

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Population

41 non-specific CLBP patients and 29 age- and sex-matched controls

Comparison

CLBP patients vs pain-free controls

Design

Cross-sectional magnetic resonance spectroscopy study

Authors

LSLaura SirucekUniversity of Zurich ISIara De SchoenmackerUniversity of Zurich LGLindsay M. GorrellUniversitätsklinik Balgrist

Discussion

Member takes

Implication

Suggests PAG imbalance as CLBP feature; leaves open causality and therapeutic targeting.

Structured PICO

Population

70 participants, including 41 patients with non-specific chronic low back pain (CLBP) (median age 54, 22 females) and 29 age- and sex-matched pain-free controls (median age 47, 17 females).

Comparator

Pain-free controls

Outcome

Ratio between pooled glutamate and glutamine and GABA levels (Glx/GABA), Glx and GABA in the periaqueductal grey (PAG)surrogate

Patients with chronic low back pain exhibit a lower excitatory/inhibitory tone in the periaqueductal grey, suggesting dysregulated descending pain modulation.

Cite This Study

Sirucek et al. (2023) studied this question.

synapsesocial.com/papers/6a1be51a26cb5670aa9d13e7 https://doi.org/10.1101/2023.06.01.23290820

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The periaqueductal grey in chronic low back pain: dysregulated metabolites and function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The periaqueductal grey in chronic low back pain: dysregulated metabolites and function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider