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August 22, 2024Human Reproduction

Long-term culture of human Sertoli cells from adult Klinefelter patients as a first step to develop new tools for unravelling the testicular physiopathology

Maria Grazia Giudice Marc Kanbar Jonathan Poels Armelle Duquenne Christine Wyns

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Abstract

Are Sertoli cells (SCs) from adult Klinefelter men (47,XXY) capable of proliferating in vitro and maintaining their main phenotypical and functional characteristics as do SCs from adult 46,XY patients?

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Cite This Study

Giudice et al. (2024) studied this question.

synapsesocial.com/papers/68e5b602b6db64358754f530 https://doi.org/10.1093/humrep/deae201

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1X-chromosome loss rescues Sertoli cell maturation and spermatogenesis in Klinefelter syndrome2024
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