Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling2025
2. 2An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation2024
3. 3GCN2 in Proteostasis: Structural Logic, Signalling Networks, and Disease2026
4. 4Structural basis for pseudokinase-mediated regulation of GCN2 in the integrated stress response2026 · 2 citations
5. 5Cryo-EM Structure of HRSL Domain Reveals Activating Crossed Helices at the Core of GCN22024