August 19, 2024Open Access

Gut Microbiota and DTI Microstructural Brain Alterations in Rodents Due to Morphine Self-Administration

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Randomized trial observes neuroinflammation and microbiota changes in rodents, indicating potential opioid intervention areas.

Altered gut microbiota diversity is observed early in the acute phase of morphine self-administration.
In MRI scans, significant changes in diffusivity indices were found in the thalamus and striatum.
Observational analysis using MRI and immunohistochemistry highlighted neuroinflammation as a key factor during morphine exposure feedback between gut and brain systems. Overall, this may enable the targeting of neuroinflammation for future opioid use disorder therapies.

Brunetti et al. (2024) studied this question.

View Full Paper

Ask AI

Bookmark