Figure 3 from Yttrium-90 Induces an Effector Memory Response with Neoantigen Clonotype Expansion: Implications for Immunotherapy

⁹⁰Y-TARE induces new clonotypes and the expansion and contraction of existing clonotypes. A, Unique clonotypes in the baseline (blue) and post-⁹⁰Y (red) and shared clonotypes between baseline and post-⁹⁰Y (purple). B, Percentage of the TCR repertoire that overlaps between baseline and post-⁹⁰Y. C, Sum frequency of clonotypes post-⁹⁰Y that were new (red) or remained from baseline (purple). D, Percentage of clonotypes shared between baseline and post-⁹⁰Y that were either expanding (green), contracting (orange), or remained unchanged (gray).