Figure 2 from Yttrium-90 Induces an Effector Memory Response with Neoantigen Clonotype Expansion: Implications for Immunotherapy

⁹⁰Y-TARE induced changes in CD8⁺ T-cell populations in early–intermediate stage HCC. A, Percentage of total CD8⁺ and (B) naïve CD8⁺ remained stable post-⁹⁰Y. The decreased percentage of (C) memory stem CD8⁺ T cells and (D) central memory CD8⁺ T cells was observed following ⁹⁰Y-TARE. An increase in the percentage of (E) effector memory/effector CD8⁺ T cells posttreatment, whereas populations of senescent T cells that were (F) CD57⁺ and (G) KLRG1⁺ remained unchanged post-⁹⁰Y. The median fluorescence intensity for the exhaustion marker (H) CTLA4 remained unchanged, whereas (I) LAG3 increased following treatment. MFI of (J) PD1 remained stable after ⁹⁰Y. Blue and red boxes represent IQR, and the solid horizontal line represents median. MFI, median fluorescence intensity; KLGR1, killer lectin–like receptor G1.