Figure 1 from Yttrium-90 Induces an Effector Memory Response with Neoantigen Clonotype Expansion: Implications for Immunotherapy

⁹⁰Y-TARE induced changes in CD4⁺ T-cell populations in early–intermediate stage HCC. A, Percentage of CD4⁺ T cells of total T cells remained stable post-⁹⁰Y, whereas (B) the percentage of naïve CD4⁺ increased following ⁹⁰Y-TARE. Decreased percentage of (C) memory stem CD4⁺ T cells and (D) central memory CD4⁺ T cells was observed following ⁹⁰Y-TARE. E, Increase in the percentage of effector memory/effector CD4⁺ T cells, whereas senescent T cells with (F) CD57⁺ and (G) KLRG1⁺ remained unchanged post-⁹⁰Y. An increase in the median fluorescence intensity for the exhaustion marker (H) CTLA4 was observed, whereas (I) LAG3 and (J) PD1 remained stable after ⁹⁰Y. Blue and red boxes represent IQR, and the solid horizontal line represents median. MFI, median fluorescence intensity; KLGR1, killer lectin–like receptor G1.