MM intra-tumor heterogeneity and survival analysis. (A) Comparison of TMA core cell-type proportions within patients and across patients. Each value in the boxplot represents the Pearson correlation coefficients between cell-type proportions across cores from different patients and cores within individual patients. (B) Kaplan-Meier survival curves of MM patients that categorized into two groups based on intra-tumor heterogeneity: those with high intra-tumor heterogeneity (Shannon entropy > 0.6 quantile) shown in blue, and those with low intra-tumor heterogeneity (Shannon entropy < 0.4 quantile) depicted in yellow.
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Ma et al. (2024) studied this question.
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