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August 15, 2024Frontiers in EndocrinologyOpen Access

Network medicine analysis for dissecting the therapeutic mechanism of consensus TCM formulae in treating hepatocellular carcinoma with different TCM syndromes

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KGKai GaoHenan UniversityWCWanchen CaoBeijing University of Chinese MedicineZHZihao HeWuhan University

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Overview

Network analysis demonstrates close proximity between herbal formulae and disease targets in hepatocellular carcinoma, highlighting a molecular rationale for syndrome-specific therapy.

Key Points

  • Gene sets from five traditional Chinese medicine formulae show significant network proximity to hepatocellular carcinoma targets, confirming syndrome-specific efficacy.
  • Network medicine analysis mapped syndrome and formula gene sets across a protein-protein interaction network, using a random walk algorithm to prioritize ingredients.
  • Findings provide a molecular basis for traditional Chinese medicine in hepatocellular carcinoma, supporting precision medicine and targeted herbal drug development.

Cite This Study

Gao et al. (2024) studied this question.

synapsesocial.com/papers/68e5c0efb6db643587558c2chttps://doi.org/10.3389/fendo.2024.1373054
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