Placental blood flow is a marker that reflects the health of the utero-placental vasculature. Dynamic contrast-enhanced (DCE) MRI is more robust than arterial spin labeling and can be utilized in animal models to provide cotyledon-specific blood flow and blood volume measurements in vivo throughout gestation. This study investigated the distribution of blood flow to the placental at a cotyledon level in pregnant rhesus monkeys before and following the injection of Tisseel (a fibrin sealant) and MCP1 (an inflammatory response inducer) to assess the predictabilities of flow for placental injury.
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Chen et al. (2024) studied this question.
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