Early assessment of utero-placental vasculature is an important novel approach to predicting pregnancy outcomes and fetal growth. Ferumoxytol-enhanced MRI is a powerful tool to measure intervillous fractional blood volume (FBV) in vivo, which could reflect structural and vascular health in the placenta. This study reports such measurements for rhesus macaque placentas that underwent localized Tisseel injections to mimic the effects of local ischemia. We observed increased regions of low FBV with gestation following the Tisseel injection.
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Chen et al. (2024) studied this question.
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