August 14, 2024Clinical Pharmacology & Therapeutics

Prediction of the Intra‐T Lymphocyte Tacrolimus Concentration after Kidney Transplantation with Population Pharmacokinetic Modeling

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Authors

SUSuwasin UdomkarnjananunThai Red Cross Society MSMaaike R. SchagenErasmus MC HVHelena VolarevićErasmus MC

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Implication

Population pharmacokinetic modeling demonstrates predictable intracellular tacrolimus exposure in kidney transplant recipients, suggesting routine blood monitoring suffices.

Key Points

Intracellular tacrolimus concentrations in CD3+ T lymphocytes remain stably proportional to whole blood levels throughout the first month after kidney transplantation.
Nonlinear mixed effects modeling showed oral clearance was associated with CYP3A5 expresser status, while 109 intracellular samples correlated with interleukin-2.
Supports predicting intracellular tacrolimus from routine whole blood samples, eliminating complex cell isolation procedures in kidney transplant recipients.

Cite This Study

Udomkarnjananun et al. (2024) studied this question.

synapsesocial.com/papers/68e5c459b6db64358755add1 https://doi.org/10.1002/cpt.3419

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Implication

Population pharmacokinetic modeling demonstrates predictable intracellular tacrolimus exposure in kidney transplant recipients, suggesting routine blood monitoring suffices.

Prediction of the Intra‐T Lymphocyte Tacrolimus Concentration after Kidney Transplantation with Population Pharmacokinetic Modeling

Discussion

Member takes

Implication

Key Points

Cite This Study

Prediction of the Intra‐T Lymphocyte Tacrolimus Concentration after Kidney Transplantation with Population Pharmacokinetic Modeling

Discussion

Member takes

Implication

Key Points

Cite This Study

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