Assessment of Splenic Switch-Off With Arterial Spin Labeling in Adenosine Perfusion Cardiac MRI

Splenic switch-off, defined as the stress to rest splenic blood flow (SBF) attenuation in response to adenosine, is an indicator of stress adequacy. This study aims to explore the ability of pseudo-continuous arterial spin labeling (PCASL) to identify splenic switch-off in patients with suspected CAD. In healthy subjects, multi-delay PCASL data were acquired to quantify SBF and determine the adequate postlabeling delay. In patients, single-delay PCASL and first-pass perfusion images were acquired under rest and adenosine conditions. This study could demonstrate the feasibility of PCASL to identify splenic switch-off during adenosine perfusion MRI.