Total White Matter Perivascular Space Volume: An Early Marker for Dutch-Type Cerebral Amyloid Angiopathy

This is the authors' abstract. We don't add key points for this paper.

In this study we semi-automatically quantified MRI-visible perivascular space volume in the white matter (WM-PVS) and compared these volumes between (pre-)symptomatic Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) and matched controls. Main findings show that the WM-PVS volume was significantly higher in symptomatic D-CAA (median=19.9mL) compared with both presymptomatic D-CAA (median=3.5mL; U=19, p=.01) and matched controls (median=4.9mL; U=1, p<.001). Presymptomatic D-CAA carriers had a higher WM-PVS volume than the matched controls (median=2.3mL; U=27, p=.02). This indicates that WM-PVS volume, in contrast to the PVS-CSO visual rating scales, may be an early marker for D-CAA.