Abnormal brain function and connectivity in patients with convergence insufficiency: A resting-state functional MRI study

Convergence insufficiency (CI) is the most common binocular vision disorder in optometric clinics relevant to the dysfunction of the specific neural circuit, while the neural mechanism is unknown. Using the fractional amplitude of low-frequency fluctuations fALFF and seed-to-voxel analysis, we found increased fALFF in the left cerebellum crus 1 and increased functional connectivity between the left cerebellum crus 1 and the right cerebellum crus 1 in patients with CI than healthy controls, which showed positive correlations with the severity of symptoms. These findings provide evidence of altered brain function features underlying neurobiological mechanisms of patients with CI.