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March 24, 2026The CerebellumOpen Access

Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia

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Authors

KPKami PearsonKAKatrina AberizkCACindy An

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Overview

Functional imaging identifies altered cerebellar network dynamics in schizophrenia, suggesting new intervention targets.

Key Points

  • This study aims to explore how effective connectivity in brain networks differs between individuals with schizophrenia and healthy controls.
  • Utilized resting-state functional magnetic resonance imaging (fMRI) data from COBRE involving schizophrenia and healthy adults.
  • Mapped cerebellar clusters with reduced ALFF and fractional ALFF using the Buckner 17-network atlas.
  • Applied Group Iterative Multiple Model Estimation (GIMME) to analyze effective connectivity patterns among brain regions.
  • Identified four cerebellar regions with lower ALFF/fALFF in schizophrenia participants compared to controls.
  • Observed distinct effective connectivity patterns between the cerebellum and prefrontal areas that were not present in healthy controls.
  • Cerebellar reorganization patterns persisted across subgroups based on positive and negative symptomology.

Cite This Study

Pearson et al. (2026) studied this question.

synapsesocial.com/papers/69c22975aeb5a845df0d3fbehttps://doi.org/10.1007/s12311-026-01983-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered cerebellar effective connectivity in first‐episode schizophrenia and long‐term changes after treatment2024 · 2 citations
  2. 2Weaker Cerebellocortical Connectivity Within Sensorimotor and Executive Networks in Schizophrenia Compared to Healthy Controls: Relationships with Processing Speed2020 · 21 citations
  3. 3Functional dysconnectivity in Schizophrenia and Bipolar Disorder: associations with cognitive impairment2025
  4. 4Functional Connectivity of Language-Related Cerebellar Regions Is Reduced in Schizophrenia Patients2024 · 2 citations
  5. 5Cerebellar dysconnectivity in schizophrenia and bipolar disorder is associated with cognitive and clinical variables2024 · 7 citations