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September 16, 2025European PsychiatryOpen Access

Functional dysconnectivity in Schizophrenia and Bipolar Disorder: associations with cognitive impairment

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Authors

GCG. Cattarinussi

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Overview

Observational analysis reveals altered functional connectivity in schizophrenia and bipolar disorder, suggesting links to cognitive functioning.

Key Points

  • Lower cerebellar functional connectivity is correlated with cognitive impairment in schizophrenia and bipolar disorder.
  • The study observed decreased cerebellar connectivity in key brain regions, indicating the complexity of cognitive deficits.
  • Functional MRI data were analyzed to reveal how connectivity relates to cognitive and clinical symptoms in patients.
  • These findings underscore the need for targeted cerebellar interventions to possibly enhance cognitive function in affected individuals.

Cite This Study

G. Cattarinussi (2025) studied this question.

synapsesocial.com/papers/68d4507331b076d99fa57bfdhttps://doi.org/10.1192/j.eurpsy.2025.103
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cerebellar dysconnectivity in schizophrenia and bipolar disorder is associated with cognitive and clinical variables2024 · 7 citations
  2. 2Functional Connectivity of Language-Related Cerebellar Regions Is Reduced in Schizophrenia Patients2024 · 2 citations
  3. 3Aberrant Intra-Cerebellar and Cerebro-Cerebellar Functional Connectivity in Early Schizophrenia Spectrum Disorder2025
  4. 4Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia2026
  5. 5Impaired Cortico-Thalamo-Cerebellar Integration Across Schizophrenia, Bipolar II, and Attention Deficit Hyperactivity Disorder Patients Suggests Potential Neural Signatures for Psychiatric Illness2024