Weaker Cerebellocortical Connectivity Within Sensorimotor and Executive Networks in Schizophrenia Compared to Healthy Controls: Relationships with Processing Speed
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Key result
Schizophrenia is linked to weaker resting connectivity between motor cerebellar lobules and temporoparietal cortices.
Why the study?
The cognitive dysmetria theory proposes that disrupted communication between the cerebellum and cerebral cortex causes psychotic symptoms and cognitive deficits in schizophrenia.
Population
Individuals with schizophrenia and healthy controls
Comparison
Individuals with schizophrenia vs healthy controls
Design
Cross-sectional functional connectivity study using publicly available data
Authors
Discussion
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Member takes
Implication
Does not yet alter schizophrenia management; extends support for cognitive dysmetria theory in observational data.
Study Design
Type
Cross-Sectional
Structured PICO
P
Population
Individuals with schizophrenia (SZ) and healthy controls (HCs)
C
Comparator
Healthy controls
O
Outcome
Resting-state functional connectivity (rsFC) between 20 hemispheric cerebellar lobules and the rest of the brainsurrogate
Disrupted cerebellocortical connectivity in schizophrenia is associated with slowed processing speed, supporting the cognitive dysmetria theory.
Cite This Study
Clark et al. (2020) conducted a cross-sectional in Schizophrenia. Schizophrenia vs. Healthy controls was evaluated on Resting-state functional connectivity (rsFC) between cerebellar lobules and cortical regions. Schizophrenia was associated with weaker resting-state functional connectivity between motor-related cerebellar lobules and temporal and parietal cortices compared to healthy controls.
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