Chemical shift saturation recovery (CSSR) MR spectroscopy using hyperpolarized xenon-129 provides metrics of pulmonary physiology by saturating the xenon dissolved-phase magnetization in the lung with a 90° RF pulse and measuring the subsequent signal recovery via gas exchange. Our measurements in a rat demonstrate that chemical shift inversion recovery (CSIR) spectroscopy, which replaces the saturation with an inversion pulse, produces equivalent results to CSSR but with greater robustness with respect to both low signal amplitudes at short delay times and incomplete saturation.
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Ruppert et al. (2024) studied this question.
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