Amide proton transfer weighted (APTw) imaging-based radiomics in the molecular subtypes prediction and grading of adult-type diffuse gliomas

The fifth edition of the 2021 WHO Classification of Tumors of the Central Nervous System (WHO CNS5) has introduced significant changes in classifying glioma subtypes based on molecular profiles. This study investigated the feasibility of amide proton transfer weighted (APTw)-based radiomics for predicting molecular subtypes and WHO grade of adult-type diffuse gliomas. APTw-based radiomics achieved satisfactory performance in distinguishing three molecular subtypes and WHO grade (High (Ⅳ grade)/Low (Ⅱ-Ⅲ grade)). This application may be an effective and promising quantitative approach for better noninvasive characterization and classification of gliomas.