Metabolic imaging of hyperpolarized pyruvate can provide new insight into tumor progression and response to therapy. Pharmacokinetic modeling can be used to determine kPL, the apparent rate constant for conversion of hyperpolarized pyruvate into lactate. In this work, we sought to characterize the effect of hyperpolarized pyruvate concentration on intracellular kPL in ATC cell suspensions using a two-compartment pharmacokinetic model for kPL quantification. Improved understanding of the effects of concentration on intracellular chemical conversion rates could lead to more accurate quantification of in vivo and clinical hyperpolarized MRI imaging biomarkers of metabolism.
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Harlan et al. (2024) studied this question.
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