Imaging analysis demonstrates reduced apparent pyruvate conversion rates in a human thyroid tumor after therapy, highlighting the need to disentangle perfusion from metabolic effects.
Dynamic contrast enhanced MRI was used to derive perfusion terms which were incorporated into the fitting of hyperpolarized pyruvate to lactate apparent conversion rates. Incorporation of the DCE data reduced the fit metabolic conversion rates across the data set but more so for the post therapy data resulting in a significant decrease in kpl after therapy. These results suggest that more effort is needed to disentangle perfusion from metabolic effects when analyzing HP MRI data.
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Walker et al. (2024) studied this question.
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