We investigated quantitative T2 mapping as an MRI biomarker for disease progression in mouse models of autosomal dominant polycystic kidney disease and its correlation with kidney function. Our results show a good correlation between the fraction of the kidney tissue with elevated T2 and cyst load quantified by histology. There was also a good correlation between high T2 values and kidney function decline indicated by reduced glomerular filtration rates.
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Schmid et al. (2024) studied this question.
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