Increased incidence of kidney diseases is a concern, for which rapid biomarkers are lacking. Changes in tubule volume fraction (TVF) is a potential biomarker for kidney disease. T2-mapping may be useful to asses TVF in noninvasive manner. To study this, we developed a protocol tailored for T2-mapping of the rat kidney, and determined a suitable numerical solution for multi-exponential decomposition of the T2-decay. Evaluation and validation of these algorithms using synthetic data and phantom showed an accuracy of 98%. This demonstrates that our approach is promising for research into quantitative assessment of renal TVF in in vivo applications.
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Tasbihi et al. (2024) studied this question.
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