Batch-mode production of hyperpolarised xenon gas with a continuous-flow polariser for preclinical and clinical human lung ventilation images

Hyperpolarised 129Xe gas was accumulated using spin-exchange optical pumping (SEOP) by continuous-flow of xenon gas directly from the cell without the use of cryogenic separation. 3D ventilation images were acquired in human and porcine models to determine clinical diagnostic image quality. Xenon ventilation image quality indicates that on demand batch production of xenon is feasible for both preclinical and clinical lung ventilation imaging examinations.