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Velocity selective arterial spin labeling (VSASL) has shown comparable CBF measurements in brain gliomas with DSC-PWI. As CBV derived from DSC-PWI is the most widely adopted perfusion marker of brain tumor angiogenesis, the clinical utility for neurooncology imaging of VSASL based CBV quantification worth investigation. This study on preoperative patients with brain gliomas demonstrated that VSASL provided highly correlated quantifications of relative tumor blood volume (R2=0.83) compared to DSC-PWI, and further improved diagnostic performance than VSASL derived relative tumor blood flow measurements (ROC AUC=0.94 vs. 0.89), indicating its potential as a viable non-contrast alternative to DSC-PWI for brain tumor applications.
Qu et al. (Wed,) studied this question.