What does this research mean for the field?

Arterial spin labeling (ASL) MRI has the potential to replace gadolinium-based contrast agents for brain tumor perfusion assessment while providing additional physiological insights such as blood-brain barrier integrity and vascular architecture. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review recent technological advances in arterial spin labeling (ASL) perfusion MRI and their clinical utility in the assessment, grading, and post-treatment monitoring of brain tumors.

August 29, 2026Magnetic Resonance Materials in Physics Biology and MedicineOpen Access

Recent advances in arterial spin labeling MRI for imaging brain tumors

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Authors

GHGabriel Hoffmann MOMatthias J.P. van Osch

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Overview

Review reveals advances in arterial spin labeling MRI for brain tumor evaluation, suggesting potential to assess vascular structure and blood-brain barrier integrity without contrast agents.

Key Points

To review recent technological advances in arterial spin labeling (ASL) perfusion MRI and their clinical utility in the assessment, grading, and post-treatment monitoring of brain tumors.
Synthesized technical developments in ASL sequences, including multi-time point and velocity-selective ASL.
Evaluated functional extensions of ASL, such as hypercapnic breathing challenges, blood-brain barrier (BBB) permeability mapping, and vessel-selective arterial labeling.
Multi-time point and velocity-selective ASL improve cerebral blood flow quantification accuracy and generate arterial transit time maps while reducing transit delay artifacts.
Novel ASL adaptations allow assessment of tumor neovascular reactivity via hypercapnic challenge and quantification of water transport across the blood-brain barrier.
Vessel-selective ASL sequences successfully identify specific arterial feeders supplying distinct tumor regions without the need for gadolinium-based contrast agents.

Cite This Study

Hoffmann et al. (2026) studied this question.

synapsesocial.com/papers/6a9299bb8e5d7d1fc0c11d7f https://doi.org/10.1007/s10334-026-01408-w

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August 29, 2026Magnetic Resonance Materials in Physics Biology and MedicineOpen Access

Recent advances in arterial spin labeling MRI for imaging brain tumors

View Full Paper

Ask AI

Bookmark

Authors

GHGabriel Hoffmann MOMatthias J.P. van Osch

Discussion

Member takes

Overview

Review reveals advances in arterial spin labeling MRI for brain tumor evaluation, suggesting potential to assess vascular structure and blood-brain barrier integrity without contrast agents.

Key Points

To review recent technological advances in arterial spin labeling (ASL) perfusion MRI and their clinical utility in the assessment, grading, and post-treatment monitoring of brain tumors.
Synthesized technical developments in ASL sequences, including multi-time point and velocity-selective ASL.
Evaluated functional extensions of ASL, such as hypercapnic breathing challenges, blood-brain barrier (BBB) permeability mapping, and vessel-selective arterial labeling.
Multi-time point and velocity-selective ASL improve cerebral blood flow quantification accuracy and generate arterial transit time maps while reducing transit delay artifacts.
Novel ASL adaptations allow assessment of tumor neovascular reactivity via hypercapnic challenge and quantification of water transport across the blood-brain barrier.
Vessel-selective ASL sequences successfully identify specific arterial feeders supplying distinct tumor regions without the need for gadolinium-based contrast agents.

Cite This Study

Hoffmann et al. (2026) studied this question.

synapsesocial.com/papers/6a9299bb8e5d7d1fc0c11d7f https://doi.org/10.1007/s10334-026-01408-w

View Full Paper

Ask AI

Bookmark