What does this research mean for the field?

Quantitative T2 relaxation time mapping of knee articular cartilage is reproducible across a wide range of clinical MRI scanners and field strengths, demonstrating low-to-moderate inter-scanner variation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To quantify the inter-scanner reproducibility of knee articular cartilage T2 relaxation time mapping across a diverse range of clinical MRI systems and field strengths.

August 23, 2026Magnetic Resonance Materials in Physics Biology and MedicineOpen Access

Reproducibility of T2 relaxation time mapping in a phantom and human knee articular cartilage

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To quantify the inter-scanner reproducibility of knee articular cartilage T2 relaxation time mapping across a diverse range of clinical MRI systems and field strengths.
Assessed T2 relaxation time mapping across 38 clinical MRI scanners at 16 imaging sites using a human volunteer knee (n = 22 at 1.5 T, n = 13 at 3 T) and a System Standard 130 phantom (n = 19 at 1.5 T, n = 12 at 3 T).
Quantified inter-scanner reproducibility using root-mean-square coefficient of variation (CV_RMS) across selected knee cartilage regions of interest and phantom T2 array vials.
Human knee cartilage regions of interest exhibited low-to-moderate inter-scanner variation, with CVs ranging from 2.2% to 22.8% (CV_RMS = 9.3% at 1.5 T; CV_RMS = 11.0% at 3 T).
Phantom measurements showed low inter-scanner variation across the typical cartilage T2 range, yielding a CV_RMS of 4.7% at 1.5 T and 2.4% at 3 T.

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Implication

Multicenter comparative study demonstrates low-to-moderate variation in knee cartilage T2 mapping across clinical MRI scanners, indicating acceptable diagnostic reproducibility.

Cite This Study

Leskinen et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad417677a341144456d8 https://doi.org/10.1007/s10334-026-01406-y

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Implication

Multicenter comparative study demonstrates low-to-moderate variation in knee cartilage T2 mapping across clinical MRI scanners, indicating acceptable diagnostic reproducibility.

Reproducibility of T2 relaxation time mapping in a phantom and human knee articular cartilage

Key Points

Discussion

Implication

Cite This Study

Reproducibility of T2 relaxation time mapping in a phantom and human knee articular cartilage

Key Points

Discussion

Implication

Cite This Study

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