Glymphatic system impairment in Parkinson’s disease with rapid movement sleep behavior disorder

To assess the activity of the glymphatic system in PD patients with probably rapid movement sleep behavior disorder (PD-pRBD) using diffusion tensor image analysis along the perivascular space( DTI-ALPS) index. 61 PD-pRBD, 92 PD patients with no probable RBD(PD-npRBD) and 59 healthy control (HC) were included in the study. The results showed that the ALPS index in PD-pRBD group was lower than that in PD-npRBD group. The index of ALPS in PD-pRBD was negatively correlated with REM sleep behavior disorder screening questionnaire(RBDSQ) score. We concluded that the glymphatic system function of PD with RBD is impaired.