Disrupted Brain Structural Network Connection in de novo Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder

To investigate the changes of white matter structural network connectivity in PD patients with probably rapid movement sleep behavior disorder (PD-pRBD). This study included PD-pRBD (n = 74) and PD with no probably RBD (PD-npRBD)(n = 97) and healthy contral (HC, n=73). The results showed that compared with the PD-npRBD group, the nodal efficiency (Ne) of the right insula and left middle frontal gyrus increased, while the Ne of the left temporal pole decreased. We conclude that changes in the right insula, left temporal pole and left middle frontal gyrus Ne may play key roles in the pathogenesis of PD-RBD.